By Navnit Shah,Harpreet Sandhu,Duk Soon Choi,Hitesh Chokshi,A. Waseem Malick
This quantity deals a finished consultant at the thought and perform of amorphous sturdy dispersions (ASD) for dealing with demanding situations linked to poorly soluble medications. In twenty-three inclusive chapters, the ebook examines thermodynamics and kinetics of the amorphous kingdom and amorphous stable dispersions, ASD applied sciences, excipients for stabilizing amorphous strong dispersions comparable to polymers, and ASD production applied sciences, together with spray drying, sizzling soften extrusion, fluid mattress layering and solvent-controlled micro-precipitation know-how (MBP). each one know-how is illustrated through particular case stories. moreover, devoted sections conceal analytical instruments and applied sciences for characterization of amorphous strong dispersions, the prediction of long term balance, and the improvement of appropriate dissolution tools and regulatory facets. The publication additionally highlights destiny applied sciences at the horizon, similar to supercritical fluid processing, mesoporous silica, KinetiSol®, and using non-salt-forming natural acids and amino acids for the stabilization of amorphous systems.
Amorphous sturdy Dispersions: idea and perform is a worthwhile connection with pharmaceutical scientists drawn to constructing bioavailable and therapeutically potent formulations of poorly soluble molecules to be able to develop those applied sciences and advance higher medications for the future.
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Extra resources for Amorphous Solid Dispersions: Theory and Practice (Advances in Delivery Science and Technology)
Amorphous Solid Dispersions: Theory and Practice (Advances in Delivery Science and Technology) by Navnit Shah,Harpreet Sandhu,Duk Soon Choi,Hitesh Chokshi,A. Waseem Malick